Статьи

Глубокий анализ программируемого открытия лекарств

AI-Driven Drug Design

15 янв. 2025 г. · 8 мин чтения

Generative AI for De Novo Molecular Design: A 2026 Perspective

A comprehensive analysis of how generative AI models are transforming de novo molecular design, with the latest methods, tools, and clinical implications.

generative AI molecular design deep learning

AI-Driven Drug Design

16 янв. 2025 г. · 7 мин чтения

AlphaFold 3 and Its Impact on Structure-Based Drug Design

How DeepMind's AlphaFold 3 is revolutionizing structure-based drug design through protein-ligand complex prediction.

AlphaFold protein structure drug design

AI-Driven Drug Design

18 янв. 2025 г. · 7 мин чтения

AI-Identified Drug Targets: From PandaOmics to Clinical Trials

Exploring how AI platforms like PandaOmics identify novel drug targets and accelerate their journey to clinical trials.

drug targets PandaOmics clinical trials

AI-Driven Drug Design

20 янв. 2025 г. · 8 мин чтения

Machine Learning ADMET Prediction: Methods and Tools

A comprehensive guide to ML-based ADMET prediction methods, tools, and their role in reducing late-stage drug failures.

ADMET machine learning pharmacokinetics

AI-Driven Drug Design

22 янв. 2025 г. · 7 мин чтения

The First AI-Designed Drug in Phase III: Rentosertib Case Study

A detailed case study of rentosertib (INS018_055), the first AI-designed drug to reach Phase III clinical trials.

rentosertib INS018_055 Insilico Medicine

Computational Pharmacology

23 янв. 2025 г. · 8 мин чтения

Free Energy Perturbation (FEP) in Lead Optimization

An in-depth analysis of FEP methods for predicting binding free energies and their transformative role in lead optimization.

FEP binding affinity lead optimization

Computational Pharmacology

24 янв. 2025 г. · 7 мин чтения

Molecular Dynamics Simulation for Drug Discovery

How molecular dynamics simulations reveal protein flexibility and dynamics to guide drug design decisions.

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Computational Pharmacology

25 янв. 2025 г. · 7 мин чтения

Quantum Computing Applications in Pharmaceutical Research

Exploring how quantum computing is beginning to transform drug discovery, from quantum chemistry to molecular simulation.

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Computational Pharmacology

26 янв. 2025 г. · 7 мин чтения

Cryo-EM Revolutionizing Structure-Based Drug Design

How cryo-electron microscopy is transforming drug discovery by enabling structural determination of previously intractable drug targets.

cryo-EM structural biology membrane proteins

Computational Pharmacology

27 янв. 2025 г. · 8 мин чтения

In Silico Toxicity Prediction: Current State and Future

A comprehensive review of computational toxicity prediction methods, from QSAR to deep learning, and their regulatory acceptance.

toxicity prediction QSAR in silico

Programmable Biology

28 янв. 2025 г. · 7 мин чтения

Programmable Proteins: Logic-Gate Drug Delivery Systems

Engineering proteins with Boolean logic operations for spatially and temporally controlled drug delivery.

programmable proteins logic gates drug delivery

Programmable Biology

29 янв. 2025 г. · 7 мин чтения

Programmable Peptides as Molecular Scaffolds: Engineering and Applications

How engineered peptide scaffolds are enabling programmable therapeutics with tunable specificity and function.

peptides molecular scaffolds protein engineering

Programmable Biology

30 янв. 2025 г. · 8 мин чтения

PROTAC Technology: Programmable Protein Degradation

How PROTACs harness the ubiquitin-proteasome system for targeted protein degradation, expanding the druggable proteome.

PROTAC protein degradation ubiquitin

Programmable Biology

31 янв. 2025 г. · 7 мин чтения

Prodrug Strategies: From Classical to AI-Driven Design

A comprehensive review of prodrug strategies from traditional chemical modification to AI-driven molecular design.

prodrugs drug activation AI design

Programmable Biology

1 февр. 2025 г. · 8 мин чтения

Antibody-Drug Conjugates (ADCs): Engineering the Next Generation

How next-generation ADCs are overcoming first-generation limitations through site-specific conjugation, novel payloads, and AI optimization.

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Industry & Regulatory

2 февр. 2025 г. · 8 мин чтения

FDA-EMA Joint AI Framework for Drug Development: What It Means

Analysis of the emerging FDA-EMA regulatory framework for AI in drug development and its implications for the pharmaceutical industry.

FDA EMA AI regulation

Industry & Regulatory

3 февр. 2025 г. · 7 мин чтения

AI Drug Discovery Market: $1.95B to $34B by 2035

A data-driven analysis of the AI drug discovery market, key growth drivers, and investment trends through 2035.

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Industry & Regulatory

4 февр. 2025 г. · 7 мин чтения

Drug Repurposing in the AI Era: Strategies and Success Stories

How AI is transforming drug repurposing from serendipity to systematic discovery, with notable success stories.

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Industry & Regulatory

5 февр. 2025 г. · 7 мин чтения

Precision Medicine and Pharmacogenomics: AI-Driven Approaches

How AI is enabling precision medicine through pharmacogenomics, biomarker discovery, and patient stratification.

precision medicine pharmacogenomics biomarkers

Industry & Regulatory

6 февр. 2025 г. · 8 мин чтения

The Cost of Drug Development: How AI Is Changing the Economics

A comprehensive analysis of drug development costs and how AI is reshaping the economics of pharmaceutical R&D.

drug development cost AI economics R&D